HEMATOPOIESIS AND STEM CELLS Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters
نویسندگان
چکیده
1Department of Molecular, Cellular, and Developmental Biology, University of California at Los Angeles, Los Angeles, CA; 2Division of Neonatology, Department of Pediatrics, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA; 3Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA; 4Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA; 5Division of Hematology-Oncology, Department of Medicine, and Department of Biologic Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA; and 6Department of Pediatrics (Craniofacial Medicine), University of Washington, Seattle, WA
منابع مشابه
Emergence of intraembryonic hematopoietic precursors in the pre-liver human embryo.
Hepatic hematopoiesis in the mouse embryo is preceded by two hematopoietic waves, one in the yolk sac, and the other in the paraaortic splanchnopleura, the presumptive aorta-gonad-mesonephros region that gives rise to prenatal and postnatal blood stem cells. An homologous intraembryonic site of stem cell emergence was previously identified at 5 weeks of human gestation, when hundreds of CD34(++...
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Duringmouse development, hematopoietic specification occurs from E7.5 in the yolk sac (YS), allantois, and chorion. Primitive hematopoiesis originating in the YS provides short-lived hematopoietic cells and progenitors for the developing embryo. Definitive hematopoietic stem cells (dHSCs), capable of long-termmultilineage hematopoietic repopulation of adult recipients, emerge only by late E10.5...
متن کاملMouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs.
During mouse development, definitive hematopoietic stem cells (dHSCs) emerge by late E10.5 to E11 in several hematopoietic sites. Of them, the aorta-gonad-mesonephros (AGM) region drew particular attention owing to its capacity to autonomously initiate and expand dHSCs in culture, indicating its key role in HSC development. The dorsal aorta contains characteristic hematopoietic clusters and is ...
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Hematopoietic cells arise first in the third week of human ontogeny inside yolk sac developing blood vessels, then, one week later and independently, from the wall of the embryonic aorta and vitelline artery. To address the suggested derivation of emerging hematopoietic stem cells from the vessel endothelium, endothelial cells have been sorted by flow cytometry from the yolk sac and aorta and c...
متن کاملEmbryonic development of the human hematopoietic system.
Human hematopoiesis is initiated in the yolk sac during the third week of development. At the same time the capacity to produce blood cells also arises in the embryo, within the splanchnopleura, but this potential is not expressed before day 27, when clustered hematopoietic stem cells emerge from the ventral wall of the aorta and vitelline artery. Budding of hematopoietic cells from vessel wall...
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